Sensitization

First, there was the observation that the use of ointments containing peanut oil increased the risk of peanut allergy. | The classical paradigm of sensitization to food occurring orally has shifted in favor of alternative routes, such as the skin and possibly the airways. | Several epidemiological observations have put the skin at the centre of attention. | Altogether, sensitization via the skin likely plays an important role in the development of food allergy. | Then, food allergy was found in the skin barrier protein that leads to impairment of barrier function.